| ZFIN ID: ZDB-EXP-230124-1 |
Experiment Conditions Description: chemical treatment by environment: caffeine, chemical treatment by environment: thapsigargin
| chemical treatment by environment: caffeine |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | caffeine |
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| Synonyms: | 1,3,7-trimethyl-2,6-dioxopurine, 1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione, 1,3,7-trimethylpurine-2,6-dione, 1,3,7-Trimethylxanthine, 1-methyltheobromine, 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion, 7-methyltheophylline, anhydrous caffeine, cafeina, cafeine, caffeine, Coffein, guaranine, Koffein, mateina, methyltheobromine, teina, Thein, theine |
| Definition: | A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee. |
| Ontology: | ChEBI [CHEBI:27732] ( EBI ) |
| chemical treatment by environment: thapsigargin |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | thapsigargin |
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| Synonyms: | (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester, Tg, Thapsigargin, thapsigargine |
| Definition: | An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. |
| Ontology: | ChEBI [CHEBI:9516] ( EBI ) |
| Publication: | Perl et al., 2022 |
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