| ZFIN ID: ZDB-EXP-210729-5 |
Experiment Conditions Description: chemical treatment by environment: edaravone, chemical treatment by environment: ponatinib
| chemical treatment by environment: edaravone |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | edaravone |
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| Synonyms: | 1-phenyl-3-methyl-5-oxo-2-pyrazoline, 2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one, 3-methyl-1-phenyl-2-pyrazolin-5-one, 3-methyl-1-phenyl-5-pyrazolone, 3-methyl-1-phenylpyrazol-5-one, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, C.I. developer 1, developer Z, Edaravone, methylphenylpyrazolone, norphenazone, phenyl methyl pyrazolone, phenylmethylpyrazolone, Radicut |
| Definition: | A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively. |
| Ontology: | ChEBI [CHEBI:31530] ( EBI ) |
| chemical treatment by environment: ponatinib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | ponatinib |
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| Synonyms: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, AP 24534, AP-24534, AP24534, ponatinib, ponatinibum |
| Definition: | A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL(T315I). |
| Ontology: | ChEBI [CHEBI:78543] ( EBI ) |
| Publication: | Zhu et al., 2020 |
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