| ZFIN ID: ZDB-EXP-210629-2 |
Experiment Conditions Description: chemical treatment: fenfluramine
| chemical treatment: fenfluramine |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | fenfluramine |
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| Synonyms: | (+-)-fenfluramine, 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane, 2-ethylamino-1-(3-trifluoromethylphenyl)propane, 3-(trifluoromethyl)-N-ethyl-alpha-methylphenethylamine, Ethyl-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-amine, fenfluramine, fenfluraminum, N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine, N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine, N-ethyl-alpha-methyl-3-trifluoromethylphenethylamine |
| Definition: | A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension. |
| Ontology: | ChEBI [CHEBI:5000] ( EBI ) |
| Publication: | Tiraboschi et al., 2020 |
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