| ZFIN ID: ZDB-EXP-210428-3 |
Experiment Conditions Description: chemical treatment by environment: 2-methyl-6-(phenylethynyl)pyridine hydrochloride, chemical treatment by environment: pentetrazol
| chemical treatment by environment: 2-methyl-6-(phenylethynyl)pyridine hydrochloride |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | 2-methyl-6-(phenylethynyl)pyridine hydrochloride |
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| Synonyms: | 2-methyl-6-(phenylethynyl)pyridine hydrochloride, 2-methyl-6-(phenylethynyl)pyridinium chloride, 6-methyl-2-(phenylethynyl)pyridine hydrochloride, 6-methyl-2-(phenylethynyl)pyridinium chloride, MPEP hydrochloride |
| Definition: | A hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. |
| Ontology: | ChEBI [CHEBI:64158] ( EBI ) |
| chemical treatment by environment: pentetrazol |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | pentetrazol |
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| Synonyms: | 1,5-pentamethylenetetrazole, 6,7,8,9-tetrahydro-5-azepotetrazole, 6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine, 7,8,9,10-tetrazabicyclo[5.3.0]-8,10-decadiene, alpha,beta-cyclopentamethylenetetrazole, Cardiazol, Cardiazole, Cardifortan, Cardiotonicum, Cardosal, Cardosan, Cenalene-M, Cenazol, Coranormol, Coratoline, Corazol, Corazole, Corvasol, Coryvet, Deumacard, Diovascole, Gewazol, Kardiazol, Korazol, Metrazol, pentamethylene-1,5-tetrazole, pentetrazol, pentetrazolum, pentylenetetrazol, Pentylenetetrazole, Phrenazol, Ventrazol |
| Definition: | An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis. |
| Ontology: | ChEBI [CHEBI:34910] ( EBI ) |
| Publication: | Kanyo et al., 2020 |
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