| ZFIN ID: ZDB-EXP-191202-2 |
Experiment Conditions Description: cancer xenotransplantation, chemical treatment: 5-fluorouracil
| cancer xenotransplantation |
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| Name: | cancer xenotransplantation |
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| Synonyms: | |
| Definition: | Xenotransplantation condition in which cancer cells are injected or grafted into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000236] |
| chemical treatment: 5-fluorouracil |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | 5-fluorouracil |
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| Synonyms: | 5-Fluoracil, 5-fluoropyrimidine-2,4(1H,3H)-dione, 5-Fluoropyrimidine-2,4-dione, 5-fluorouracil, 5-FU, fluorouracil, fluorouracilo, fluorouracilum |
| Definition: | A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. |
| Ontology: | ChEBI [CHEBI:46345] ( EBI ) |
| Publication: | Zhu et al., 2019 |
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