| ZFIN ID: ZDB-EXP-181205-5 |
Experiment Conditions Description: chemical treatment by environment: cobimetinib
| chemical treatment by environment: cobimetinib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | cobimetinib |
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| Synonyms: | [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone, cobimetinib, GDC 0973, GDC-0973, GDC0973, RG 7420, RG7420, Xl 518, Xl-518, XL518 |
| Definition: | A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma. |
| Ontology: | ChEBI [CHEBI:90851] ( EBI ) |
| Publication: | Li et al., 2018 |
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