| ZFIN ID: ZDB-EXP-180328-4 |
Experiment Conditions Description: chemical treatment by environment: 7,8-dihydroxyflavone, chemical treatment by environment: ANA-12
| chemical treatment by environment: 7,8-dihydroxyflavone |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | 7,8-dihydroxyflavone |
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| Synonyms: | 7,8-DHF, 7,8-dihydroxy-2-phenyl-4-benzopyrone, 7,8-dihydroxy-2-phenyl-4H-chromen-4-one, 7,8-dihydroxy-2-phenylchromone |
| Definition: | A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's. |
| Ontology: | ChEBI [CHEBI:140464] ( EBI ) |
| chemical treatment by environment: ANA-12 |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | ANA-12 |
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| Synonyms: | ANA12, N-{2-[(2-oxoazepan-3-yl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide, TrkB antagonist |
| Definition: | A secondary carboxamide that is anthranilic acid in which the carboxy group has undergone condensation with the primary amino group of alpha-amino-epsilon-caprolactam, while the aryl-amino group has undergone condensation with the carboxy group of 1-benzothiophene-2-carboxylic acid. It is a selective, non-competitive antagonist of tropomyosin receptor kinase B (TrkB, also known as tyrosine receptor kinase B). |
| Ontology: | ChEBI [CHEBI:140465] ( EBI ) |
| Publication: | Daly et al., 2017 |
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