| ZFIN ID: ZDB-EXP-180201-10 |
Experiment Conditions Description: fasting, chemical treatment: dorsomorphin, chemical treatment: 8-bromo-3',5'-cyclic GMP
| fasting |
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| Name: | fasting |
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| Synonyms: | |
| Definition: | Limited food availability condition in which there is no food provided. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000114] |
| chemical treatment: dorsomorphin |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | dorsomorphin |
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| Synonyms: | 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine, compound C |
| Definition: | A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. |
| Ontology: | ChEBI [CHEBI:78510] ( EBI ) |
| chemical treatment: 8-bromo-3',5'-cyclic GMP |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | 8-bromo-3',5'-cyclic GMP |
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| Synonyms: | 8-Br-cGMP, 8-Br-Cyclic GMP, 8-Bromo-cgmp, 8-Bromocyclic GMP, 8-Bromocyclic guanosine monophosphate, 8-bromoguanosine 3',5'-(hydrogen phosphate), 8-Bromoguanosine 3',5'-cyclic monophosphate, 8-Bromoguanosine 3',5'-monophosphate |
| Definition: | A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. |
| Ontology: | ChEBI [CHEBI:64108] ( EBI ) |
| Publication: | Gu et al., 2014 |
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