| ZFIN ID: ZDB-EXP-171129-4 |
Experiment Conditions Description: chemical treatment: low-density lipoprotein cholesterol, chemical treatment: simvastatin
| chemical treatment: low-density lipoprotein cholesterol |
|---|
| Name: | chemical treatment |
|---|---|
| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | low-density lipoprotein cholesterol |
|---|---|
| Synonyms: | beta-lipoprotein cholesterol, LDL cholesterol, LDL-C |
| Definition: | Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL). |
| Ontology: | ChEBI [CHEBI:47774] ( EBI ) |
| chemical treatment: simvastatin |
|---|
| Name: | chemical treatment |
|---|---|
| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | simvastatin |
|---|---|
| Synonyms: | (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate, 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one, MK-733, Simvastatin, Simvastatina, Simvastatine, Simvastatinum, Zocor |
| Definition: | A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. |
| Ontology: | ChEBI [CHEBI:9150] ( EBI ) |
| Publication: | Campos et al., 2015 |
|---|