| ZFIN ID: ZDB-EXP-161107-3 |
Experiment Conditions Description: chemical treatment by environment: 6-bromoindirubin-3'-oxime, chemical treatment by environment: aristolochic acid A
| chemical treatment by environment: 6-bromoindirubin-3'-oxime |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | 6-bromoindirubin-3'-oxime |
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| Synonyms: | (2Z,3E)-6'-bromo-2,3'-biindole-2',3(1H,1'H)-dione 3-oxime, (2Z,3E)-6-Bromoindirubin-3'-oxime, (3Z)-6-bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one, 6-BIO |
| Definition: | A member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime. |
| Ontology: | ChEBI [CHEBI:86290] ( EBI ) |
| chemical treatment by environment: aristolochic acid A |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | aristolochic acid A |
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| Synonyms: | 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid, 8-methoxy-6-nitro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid, 8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid, Aristolochic acid, aristolochic acid A, Aristolochic acid I, aristolochic acid-I, aristolochin |
| Definition: | An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. |
| Ontology: | ChEBI [CHEBI:2825] ( EBI ) |
| Publication: | Kim et al., 2016 |
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