| ZFIN ID: ZDB-EXP-250313-4 |
Experiment Conditions Description: bacterial treatment by injection: Mycobacterium marinum, chemical treatment by environment: CK-666
| bacterial treatment by injection: Mycobacterium marinum |
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| Name: | bacterial treatment by injection |
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| Synonyms: | |
| Definition: | Bacterial treatment where the bacteria are injected into the fish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000230] |
| Name: | Mycobacterium marinum |
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| Synonyms: | Mycobacterium balnei, Mycobacterium platypoecilus |
| Definition: | |
| Ontology: | Taxonomy for ZECO [NCBITaxon:1781] |
| chemical treatment by environment: CK-666 |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | CK-666 |
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| Synonyms: | 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide, CK 666, CK-0944666, CK666 |
| Definition: | A member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. |
| Ontology: | ChEBI [CHEBI:78843] ( EBI ) |
| Publication: | Saelens et al., 2022 |
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