ZFIN ID: ZDB-EXP-250308-8
Experiment Conditions Description: chemical treatment by environment: 4-phenylbutyric acid, chemical treatment by environment: tunicamycin
chemical treatment by environment: 4-phenylbutyric acid
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: 4-phenylbutyric acid
Synonyms: 4-PHENYL-BUTANOIC ACID, 4-Phenyl-n-butyric acid, 4-phenylbutanoic acid, Benzenebutyric acid, gamma-Phenyl-n-butyric acid, gamma-phenylbutyric acid, omega-Phenylbutanoic acid, omega-phenylbutyric acid, PBA
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Ontology: ChEBI [CHEBI:41500]  ( EBI )
chemical treatment by environment: tunicamycin
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: tunicamycin
Synonyms: Tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Ontology: ChEBI [CHEBI:29699]  ( EBI )
Publication: Ellis et al., 2022