Transgenic Construct
Tg(actb2:stx4_R41W-IRES-EGFP,cryaa:DsRed)
- ID
- ZDB-TGCONSTRCT-221212-5
- Name
- Tg(actb2:stx4_R41W-IRES-EGFP,cryaa:DsRed)
- Previous Names
-
- Tg(actb2:stx4-R241W-IRES-EGFP) (1)
- Type
- engineered_plasmid
- Regulatory Regions
- Coding Sequences
- Contains Sequences
- None
- Note
-
This construct expresses an engineered mutant form of the zebrafish stx4 gene analogous to the STX4 allele found in a homozygous human patient who displayed biventricular dilated cardiomyopathy, ectopy, runs of non-sustained ventricular tachycardia, sensorineural hearing loss, global developmental delay, and hypotonia Perl et al (2022), ZDB-PUB-220524-4, PubMed:35599850
Plasmid Map
None
Genomic Features
That Utilize tg(actb2:stx4_r41w-ires-egfp,cryaa:dsred) Construct
| Genomic Feature | Affected Genomic Regions |
|---|---|
| ci1019Tg |
Transgenics
That Utilize tg(actb2:stx4_r41w-ires-egfp,cryaa:dsred) Construct
| Fish | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|
| ci1019Tg/+ |
|
Fig. 6
from
Perl et al., 2022
|
|
| stx4ci1016/ci1016; ci1019Tg/+ |
Fig. 6
from
Perl et al., 2022
|
Sequence Information
Other Construct Pages
None
Citations