TALEN

TALEN1-apobb.1

ID

ZDB-TALEN-191216-1

Name

TALEN1-apobb.1

Previous Names

None

Target

apobb.1 (1)

Target Sequence 1

5' - GAGCTTCCTCTCCCAT - 3'

Target Sequence 2

5' - TTCTGTTCAGAATGAC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
c832Tg	apobb.1

Expression

Gene expression in Wild Types + TALEN1-apobb.1

No data available

Phenotype

Phenotype resulting from TALEN1-apobb.1

No data available

Phenotype of all Fish created by or utilizing TALEN1-apobb.1

Phenotype	Fish	Conditions	Figures
whole organism intermediate-density lipoprotein increased amount, abnormal	apobb.1^c832Tg/+ (AB)	fasting	Fig. 3 from Thierer et al., 2019
whole organism very-low-density lipoprotein decreased amount, abnormal	apobb.1^c832Tg/+ (AB)	chemical treatment: lomitapide	Fig. 3 from Thierer et al., 2019
whole organism Luciferase expression decreased amount, abnormal	apobb.1^c832Tg/+ (AB)	chemical treatment: lomitapide	Fig. 2 from Thierer et al., 2019
whole organism intermediate-density lipoprotein increased amount, abnormal	apobb.1^c832Tg/+ (AB)	chemical treatment: lomitapide	Fig. 3 from Thierer et al., 2019
whole organism low-density lipoprotein increased amount, abnormal	apobb.1^c832Tg/+ (AB)	chemical treatment: lomitapide	Fig. 3 from Thierer et al., 2019
whole organism Luciferase expression decreased amount, abnormal	apobb.1^c832Tg/+ (AB)	fasting	Fig. 2 from Thierer et al., 2019
head Luciferase expression decreased amount, abnormal	apobb.1^c832Tg/+ (AB)	chemical treatment: lomitapide	Fig. 5 from Thierer et al., 2019
digestive system Luciferase expression decreased amount, abnormal	apobb.1^c832Tg/+ (AB)	fasting	Fig. 5 from Thierer et al., 2019
digestive system Luciferase expression increased amount, abnormal	apobb.1^c832Tg/+ (AB)	chemical treatment: lomitapide	Fig. 5 from Thierer et al., 2019
whole organism intermediate-density lipoprotein decreased amount, abnormal	apobb.1^c832Tg/+; apoc2^sd38/sd38 (AB)	standard conditions	Fig. 3 from Thierer et al., 2019
whole organism low-density lipoprotein decreased amount, abnormal	apobb.1^c832Tg/+; apoc2^sd38/sd38 (AB)	standard conditions	Fig. 3 from Thierer et al., 2019
whole organism very-low-density lipoprotein increased amount, abnormal	apobb.1^c832Tg/+; apoc2^sd38/sd38 (AB)	standard conditions	Fig. 3 from Thierer et al., 2019
whole organism Luciferase expression increased amount, abnormal	apobb.1^c832Tg/+; apoc2^sd38/sd38 (AB)	standard conditions	Fig. 2, Fig. 5 from Thierer et al., 2019
liver lipoprotein particle increased amount, abnormal	mttp^c655/c655; apobb.1^c832Tg	standard conditions	Fig 3 from Wilson et al., 2020
whole organism very-low-density lipoprotein particle decreased amount, abnormal	mttp^c655/c655; apobb.1^c832Tg	standard conditions	Fig 3 from Wilson et al., 2020
whole organism lipoprotein particle decreased amount, abnormal	mttp^c655/c655; apobb.1^c832Tg	standard conditions	Fig 3 from Wilson et al., 2020
trunk Luciferase expression decreased amount, abnormal	mttp^y79/y79; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 5 from Thierer et al., 2019
whole organism very-low-density lipoprotein decreased amount, abnormal	mttp^y79/y79; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 3 from Thierer et al., 2019
head Luciferase expression decreased amount, abnormal	mttp^y79/y79; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 5 from Thierer et al., 2019
whole organism Luciferase expression decreased amount, abnormal	mttp^y79/y79; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 2, Fig. 5 from Thierer et al., 2019
digestive system Luciferase expression increased amount, abnormal	mttp^y79/y79; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 5 from Thierer et al., 2019
whole organism low-density lipoprotein increased amount, abnormal	mttp^y79/y79; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 3 from Thierer et al., 2019
intestine lipoprotein particle increased amount, abnormal	mttp^y79; apobb.1^c832Tg	standard conditions	Fig 3 from Wilson et al., 2020
whole organism very-low-density lipoprotein particle decreased amount, abnormal	mttp^y79; apobb.1^c832Tg	standard conditions	Fig 3 from Wilson et al., 2020
whole organism lipoprotein particle decreased amount, abnormal	mttp^y79; apobb.1^c832Tg	standard conditions	Fig 3 from Wilson et al., 2020
whole organism intermediate-density lipoprotein increased amount, abnormal	pla2g12b^sa659/sa659; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 6 from Thierer et al., 2019
head Luciferase expression decreased amount, abnormal	pla2g12b^sa659/sa659; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 6 from Thierer et al., 2019
whole organism Luciferase expression decreased amount, abnormal	pla2g12b^sa659/sa659; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 6 from Thierer et al., 2019
whole organism very-low-density lipoprotein decreased amount, abnormal	pla2g12b^sa659/sa659; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 6 from Thierer et al., 2019
digestive system Luciferase expression increased amount, abnormal	pla2g12b^sa659/sa659; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 6 from Thierer et al., 2019
whole organism low-density lipoprotein increased amount, abnormal	pla2g12b^sa659/sa659; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 6 from Thierer et al., 2019
trunk Luciferase expression decreased amount, abnormal	pla2g12b^sa659/sa659; apobb.1^c832Tg/+ (AB)	standard conditions	Fig. 6 from Thierer et al., 2019

Citations