PUBLICATION
oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet
- Authors
- Malicki, J. and Driever, W.
- ID
- ZDB-PUB-990302-43
- Date
- 1999
- Source
- Development (Cambridge, England) 126: 1235-1246 (Journal)
- Registered Authors
- Driever, Wolfgang, Malicki, Jarema
- Keywords
- none
- MeSH Terms
-
- Animals
- Blastomeres
- Brain/embryology
- Cell Communication*
- Cell Differentiation
- Cell Transplantation
- Epithelial Cells/cytology*
- Mutation*
- Neurons/cytology*
- Retina/embryology*
- Superior Colliculi/surgery
- Zebrafish/embryology
- Zebrafish/genetics
- PubMed
- 10021342 Full text @ Development
Citation
Malicki, J. and Driever, W. (1999) oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet. Development (Cambridge, England). 126:1235-1246.
Abstract
Mutations of the oko meduzy (ome) locus cause drastic neuronal patterning defect in the zebrafish retina. The precise, stratified appearance of the wild-type retina is absent in the mutants. Despite the lack of lamination, at least seven retinal cell types differentiate in oko meduzy. The ome phenotype is already expressed in the retinal neuroepithelium affecting morphology of the neuroepithelial cells. Our experiments indicate that previously unknown cell-cell interactions are involved in development of the retinal neuroepithelial sheet. In genetically mosaic animals, cell-cell interactions are sufficient to rescue the phenotype of oko meduzy retinal neuroepithelial cells. These cell-cell interactions may play a critical role in the patterning events that lead to differentiation of distinct neuronal laminae in the vertebrate retina.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping