PUBLICATION

Cloning and genetic mapping of zebrafish BMP-2

Authors
Lee, K.H., Marden, J.J., Thompson, M.S., MacLennan, H., Kishimoto, Y., Pratt, S.J., Schulte-Merker, S., Hammerschmidt, M., Johnson, S.L., Postlethwait, J.H., Beier, D.C., and Zon, L.I.
ID
ZDB-PUB-981027-3
Date
1998
Source
Developmental genetics   23: 97-103 (Journal)
Registered Authors
Hammerschmidt, Matthias, Johnson, Stephen L., Kishimoto, Yasuyuki, Lee, Kyu-Ho, Postlethwait, John H., Pratt, Stephen J., Schulte-Merker, Stefan, Zon, Leonard I.
Keywords
bone morphogenetic protein; zebrafish; genetics
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins/biosynthesis
  • Bone Morphogenetic Proteins/genetics*
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA, Complementary/genetics
  • Embryo, Nonmammalian/metabolism
  • Embryo, Nonmammalian/ultrastructure
  • Gene Expression Regulation, Developmental
  • Genes*
  • Molecular Sequence Data
  • Mutation, Missense
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Transforming Growth Factor beta*
  • Zebrafish/embryology
  • Zebrafish/genetics*
PubMed
9770266 Full text @ Dev. Genet.
Abstract
The BMP family of polypeptide growth factors has been shown to play diverse roles in establishing embryonic patterning and tissue fates. We report the cloning of the zebrafish homologue of BMP-2, examine its expression during embryogenesis, and find that it is localized to the distal end of the long arm of zebrafish chromosome 20. A missense mutation of the bmp2 gene has recently been shown to be responsible for the early dorsalized phenotype of the zebrafish swirl mutant [Kishimoto et al., 1997]. Given the dynamic expression of bmp2 in the developing embryo and the complex interactions of BMP signaling response in vertebrates, it is possible that other mutant phenotypes, due to altered bmp2 gene expression, will eventually map to or interact with this genetic locus.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping