PUBLICATION
A homeobox gene essential for zebrafish notochord development
- Authors
- Talbot, W.S., Trevarrow, B., Halpern, M.E., Melby, A.E., Farr, G., Postlethwait, J.H., Jowett, T., Kimmel, C.B., and Kimelman, D.
- ID
- ZDB-PUB-961014-1111
- Date
- 1995
- Source
- Nature 378: 150-157 (Journal)
- Registered Authors
- Halpern, Marnie E., Jowett, Trevor, Kimelman, David, Kimmel, Charles B., Melby, Bess, Postlethwait, John H., Talbot, William S., Trevarrow, Bill
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Differentiation/genetics
- Chromosome Mapping
- DNA Primers
- DNA-Binding Proteins/genetics
- Gastrula/cytology
- Genes, Homeobox*
- Genes, Lethal
- Hedgehog Proteins
- Homeodomain Proteins/genetics*
- Humans
- Mesoderm/cytology
- Molecular Sequence Data
- Motor Neurons/cytology
- Mutation
- Notochord/embryology*
- Proteins/genetics
- RNA, Messenger/biosynthesis
- Stem Cells/cytology
- Tail
- Trans-Activators/genetics
- Transcription Factors/genetics*
- Xenopus Proteins*
- Zebrafish
- Zebrafish Proteins*
- PubMed
- 7477317 Full text @ Nature
Citation
Talbot, W.S., Trevarrow, B., Halpern, M.E., Melby, A.E., Farr, G., Postlethwait, J.H., Jowett, T., Kimmel, C.B., and Kimelman, D. (1995) A homeobox gene essential for zebrafish notochord development. Nature. 378:150-157.
Abstract
The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping