PUBLICATION
Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction
- Authors
- Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F.
- ID
- ZDB-PUB-220929-23
- Date
- 2022
- Source
- The FEBS journal 290(6): 1519-1530 (Journal)
- Registered Authors
- Keywords
- 15-PGDH, AMPK/SIRT1/PGC-1α, Exercise, Mitochondrial Homeostasis, Sarcopenia
- MeSH Terms
-
- Animals
- Exercise Therapy*
- Humans
- Mitochondria*/metabolism
- Mitochondrial Diseases*/genetics
- Mitochondrial Diseases*/metabolism
- Mitochondrial Diseases*/prevention & control
- Muscle, Skeletal*/metabolism
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
- Sarcopenia*/genetics
- Sarcopenia*/prevention & control
- Zebrafish*/genetics
- Zebrafish*/metabolism
- PubMed
- 36164851 Full text @ FEBS J.
Citation
Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2022) Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. The FEBS journal. 290(6):1519-1530.
Abstract
Sarcopenia is a common disorder that leads to a progressive decrease in skeletal muscle function in elderly people. Exercise effectively prevents or delays the onset and progression of sarcopenia. However, the molecular mechanisms underlying how exercise intervention improves skeletal muscle atrophy remain unclear. In this study, we found that 21-month-old zebrafish had a decreased swimming ability, reduced muscle fiber cross-sectional area, unbalanced protein synthesis, and degradation, increased oxidative stress, and mitochondrial dysfunction, which suggests zebrafish are a valuable model for sarcopenia. Eight weeks of exercise intervention attenuated these pathological changes in sarcopenia zebrafish. Moreover, the effects of exercise on mitochondrial dysfunction were associated with the activation of the AMPK/SIRT1/PGC-1α axis and 15-PGDH downregulation. Our results reveal potential therapeutic targets and indicators to treat age-related sarcopenia using exercise intervention.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping