PUBLICATION
The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish
- Authors
- Anneser, L., Gemmer, A., Eilers, T., Alcantara, I.C., Loos, A.Y., Ryu, S., Schuman, E.M.
- ID
- ZDB-PUB-220305-8
- Date
- 2022
- Source
- iScience 25: 103868 (Journal)
- Registered Authors
- Anneser, Lukas, Loos, Anett-Yvonn, Ryu, Soojin, Schuman, Erin
- Keywords
- Behavioral neuroscience, Biological sciences, Molecular neuroscience
- MeSH Terms
- none
- PubMed
- 35243231 Full text @ iScience
Citation
Anneser, L., Gemmer, A., Eilers, T., Alcantara, I.C., Loos, A.Y., Ryu, S., Schuman, E.M. (2022) The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish. iScience. 25:103868.
Abstract
Behavior is context-dependent and often modulated by an animal's internal state. In particular, different social contexts can alter anxiety levels and modulate social behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 (pth2) is regulated by the presence of conspecifics in zebrafish. As its cognate receptor, the parathyroid hormone 2 receptor (pth2r), is widely expressed across the brain, we tested fish lacking the functional Pth2 peptide in several anxiety-related and social behavior paradigms. Here, we show that the propensity to react to sudden stimuli with an escape response was increased in pth2-/- zebrafish, consistent with an elevated anxiety level. While overall social preference for conspecifics was maintained in pth2-/- fish until the early juvenile stage, we found that both social preference and shoaling were altered later in development. The data presented suggest that the neuropeptide Pth2 modulates several conserved behaviors and may thus enable the animal to react appropriately in different social contexts.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping