PUBLICATION
Schwann cell precursors generate sympathoadrenal system during zebrafish development
- Authors
- Kamenev, D., Sunadome, K., Shirokov, M., Chagin, A.S., Singh, A., Irion, U., Adameyko, I., Fried, K., Dyachuk, V.
- ID
- ZDB-PUB-210630-6
- Date
- 2021
- Source
- Journal of neuroscience research 99(10): 2540-2557 (Journal)
- Registered Authors
- Irion, Uwe
- Keywords
- GTX128374, RRID:AB_10615776, RRID:AB_162542, RRID:AB_2313713, RRID:AB_2716636, RRID:AB_2762830, RRID:AB_2762834, RRID:AB_2861427, RRID:AB_2887225, RRID:AB_303395, RRID:SCR_002798, RRID:SCR_003070, RRID:SCR_007370, RRID:SCR_018163, axons, chromaffin cells, motor neurons, neurogenesis, sympathetic neurons, teleost fish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Cell Movement/physiology*
- Neural Stem Cells/physiology*
- Neurogenesis/physiology*
- Schwann Cells/physiology*
- Sympathoadrenal System/cytology
- Sympathoadrenal System/physiology*
- Zebrafish
- PubMed
- 34184294 Full text @ J. Neurosci. Res.
Citation
Kamenev, D., Sunadome, K., Shirokov, M., Chagin, A.S., Singh, A., Irion, U., Adameyko, I., Fried, K., Dyachuk, V. (2021) Schwann cell precursors generate sympathoadrenal system during zebrafish development. Journal of neuroscience research. 99(10):2540-2557.
Abstract
The autonomic portion of the peripheral nervous system orchestrates tissue homeostasis through direct innervation of internal organs, and via release of adrenalin and noradrenalin into the blood flow. The developmental mechanisms behind the formation of autonomic neurons and chromaffin cells are not fully understood. Using genetic tracing, we discovered that a significant proportion of sympathetic neurons in zebrafish originates from Schwann cell precursors (SCPs) during a defined period of embryonic development. Moreover, SCPs give rise to the main portion of the chromaffin cells, as well as to a significant proportion of enteric and other autonomic neurons associated with internal organs. The conversion of SCPs into neuronal and chromaffin cells is ErbB receptor dependent, as the pharmacological inhibition of the ErbB pathway effectively perturbed this transition. Finally, using genetic ablations, we revealed that SCPs producing neurons and chromaffin cells migrate along spinal motor axons to reach appropriate target locations. This study reveals the evolutionary conservation of SCP-to-neuron and SCP-to-chromaffin cell transitions over significant growth periods in fish and highlights relevant cellular-genetic mechanisms. Based on this, we anticipate that multipotent SCPs might be present in postnatal vertebrate tissues, retaining the capacity to regenerate autonomic neurons and chromaffin cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping