PUBLICATION

Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections

Authors
Jacobs, S.H., Dóró, E., Hammond, F.R., Nguyen-Chi, M.E., Lutfalla, G., Wiegertjes, G.F., Forlenza, M.
ID
ZDB-PUB-210612-2
Date
2021
Source
eLIFE   10: (Journal)
Registered Authors
Lutfalla, Georges
Keywords
infectious disease, microbiology, zebrafish
MeSH Terms
  • Animals
  • Cell Proliferation
  • Disease Models, Animal
  • Humans
  • Immunity, Innate
  • Inflammation/immunology
  • Larva/immunology
  • Macrophages/immunology*
  • Macrophages/metabolism
  • Neutrophils/immunology*
  • Neutrophils/metabolism
  • Phagocytosis
  • Trypanosoma/immunology*
  • Trypanosomiasis/immunology*
  • Zebrafish/immunology
PubMed
34114560 Full text @ Elife
Abstract
A tightly regulated innate immune response to trypanosome infections is critical to strike a balance between parasite control and inflammation-associated pathology. In this study, we make use of the recently established Trypanosoma carassii infection model in larval zebrafish to study the early response of macrophages and neutrophils to trypanosome infections in vivo. We consistently identified high- and low-infected individuals and were able to simultaneously characterize their differential innate response. Not only did macrophage and neutrophil number and distribution differ between the two groups, but also macrophage morphology and activation state. Exclusive to high-infected zebrafish, was the occurrence of foamy macrophages characterized by a strong pro-inflammatory profile and potentially associated with an exacerbated immune response as well as susceptibility to the infection. To our knowledge this is the first report of the occurrence of foamy macrophages during an extracellular trypanosome infection.
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