PUBLICATION
Sarm1 is dispensable for mechanosensory-motor transformations in zebrafish
- Authors
- Asgharsharghi, A., Tian, W., Haehnel-Taguchi, M., López-Schier, H.
- ID
- ZDB-PUB-210311-2
- Date
- 2021
- Source
- microPublication. Biology 2021: (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 33688624 Full text @ MicroPubl Biol
Citation
Asgharsharghi, A., Tian, W., Haehnel-Taguchi, M., López-Schier, H. (2021) Sarm1 is dispensable for mechanosensory-motor transformations in zebrafish. microPublication. Biology. 2021:.
Abstract
Sarm1 is an evolutionary conserved protein that is essential for Wallerian axon degeneration. Sarm1 has emerged as a therapeutic target to treat neuropathies derived from metabolic or chemical stress and physical injury of axons. Yet, the full repertoire of consequences of inhibiting Sarm1 remains unknown. Here we show that loss of Sarm1 in zebrafish does not affect the sensorimotor transformations that underlie rheotaxis. In addition, Sarm1 deficit accelerates the re-growth of regenerating axons. These data indicate that systemic inhibition of Sarm1 is a viable therapeutic option compatible with sustained nervous system function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping