PUBLICATION
The major vault protein is dispensable for zebrafish organ regeneration
- Authors
- Zhang, X., Yang, Y., Bu, X., Wei, Y., Lou, X.
- ID
- ZDB-PUB-201120-140
- Date
- 2020
- Source
- Heliyon 6: e05422 (Journal)
- Registered Authors
- Lou, Xin
- Keywords
- Anti-apoptotic effect, Biological sciences, Cell biology, Cell death, Developmental genetics, Knockout, Major vault protein, Regeneration, Regenerative medicine, Zebrafish
- Datasets
- GEO:GSE157170
- MeSH Terms
- none
- PubMed
- 33195847 Full text @ Heliyon
Citation
Zhang, X., Yang, Y., Bu, X., Wei, Y., Lou, X. (2020) The major vault protein is dispensable for zebrafish organ regeneration. Heliyon. 6:e05422.
Abstract
As the main constituent of the largest cellular ribonucleoprotein complex, the evolutionary highly conserved major vault protein (MVP) has been proposed play vital roles in the regeneration of multiple organs. In current study, we use a mvp knockout zebrafish line recently generated to characterize the function of MVP during organ regeneration. We found the regenerative capacity of heart, spinal cord and fin is preserved in mvp knockout zebrafish. Further experiments demonstrated in injured mvp knockout zebrafish, the cell death is enhanced while the transcriptome landscape is largely unchanged. These data showed MVP acts as an anti-apoptotic factor at early phase of injury response while plays a dispensable role in the regenerative programs in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping