PUBLICATION
An Acromegaly Disease Zebrafish Model Reveals Decline in Body Stem Cell Number along with Signs of Premature Aging
- Authors
- Elbialy, A., Igarashi, Y., Asakawa, S., Watabe, S., Kinoshita, S.
- ID
- ZDB-PUB-200611-2
- Date
- 2020
- Source
- Biology 9(6): (Journal)
- Registered Authors
- Kinoshita, Shigeharu, Watabe, Shugo
- Keywords
- acromegaly, aging, growth hormone, stem cell, zebrafish
- Datasets
- GEO:GSE113169
- MeSH Terms
- none
- PubMed
- 32517323 Full text @ Biology (Basel)
Citation
Elbialy, A., Igarashi, Y., Asakawa, S., Watabe, S., Kinoshita, S. (2020) An Acromegaly Disease Zebrafish Model Reveals Decline in Body Stem Cell Number along with Signs of Premature Aging. Biology. 9(6):.
Abstract
In our previous publication, it was shown that growth hormone (GH) excess in acromegaly affects the cell integrity of somatic cells through increased DNA damage throughout the body and impaired DNA repair pathways. Acromegaly is a hormone disorder pathological condition that develops as a result of growth hormone over-secretion from the pituitary gland. We produced a zebrafish acromegaly model to gain a better understanding of the excess GH effects at the cellular level. Here we show that the acromegaly zebrafish model progressively reduced the number of stem cells in different organs and increased oxidative stress in stem cells. Importantly, the decline in the stem cells was even more apparent than in aged fish. The controversy and debate over the use of GH as an anti-aging therapy have been going on for several years. In this study, excess GH induced aging signs such as increased senescence-associated (SA)-β-galactosidase staining of abdominal skin and similarity of the pattern of gene expression between aged and acromegaly zebrafish. Thus, this study highlights the role of excess GH in acromegaly stem cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping