PUBLICATION
The Polycomb Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model
- Authors
- Raby, L., Völkel, P., Le Bourhis, X., Angrand, P.O.
- ID
- ZDB-PUB-200403-217
- Date
- 2020
- Source
- Genes 11(4): (Journal)
- Registered Authors
- Angrand, Pierre-Olivier, Raby, Ludivine, Völkel, Pamela
- Keywords
- CBX, Teleost fishes, phylogenetic analysis, polycomb group proteins, zebrafish
- MeSH Terms
-
- Animals
- Cell Differentiation
- Cell Nucleus/genetics
- Cell Nucleus/metabolism
- Chromatin/genetics
- Chromatin/metabolism*
- Fish Proteins/genetics*
- Fish Proteins/metabolism
- Fishes/genetics*
- Fishes/growth & development
- Gene Duplication*
- Gene Expression Regulation, Developmental*
- Genome
- Polycomb-Group Proteins/genetics*
- Polycomb-Group Proteins/metabolism
- Zebrafish/genetics*
- Zebrafish/growth & development
- PubMed
- 32230868 Full text @ Genes (Basel)
Citation
Raby, L., Völkel, P., Le Bourhis, X., Angrand, P.O. (2020) The Polycomb Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model. Genes. 11(4):.
Abstract
The Polycomb Repressive Complex 1 (PRC1) is a chromatin-associated protein complex involved in transcriptional repression of hundreds of genes controlling development and differentiation processes, but also involved in cancer and stem cell biology. Within the canonical PRC1, members of Pc/CBX protein family are responsible for the targeting of the complex to specific gene loci. In mammals, the Pc/CBX protein family is composed of five members generating, through mutual exclusion, different PRC1 complexes with potentially distinct cellular functions. Here, we performed a global analysis of the cbx gene family in 68 teleost species and traced the distribution of the cbx genes through teleost evolution in six fish super-orders. We showed that after the teleost-specific whole genome duplication, cbx4, cbx7 and cbx8 are retained as pairs of ohnologues. In contrast, cbx2 and cbx6 are present as pairs of ohnologues in the genome of several teleost clades but as singletons in others. Furthermore, since zebrafish is a widely used vertebrate model for studying development, we report on the expression of the cbx family members during zebrafish development and in adult tissues. We showed that all cbx genes are ubiquitously expressed with some variations during early development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping