PUBLICATION
Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development
- Authors
- Guillon, E., Das, D., Jülich, D., Hassan, A.R., Geller, H., Holley, S.
- ID
- ZDB-PUB-200403-215
- Date
- 2020
- Source
- eLIFE 9: (Journal)
- Registered Authors
- Holley, Scott, Jülich, Dörthe
- Keywords
- biomechanics, cadherin, cell biology, computational modeling, developmental biology, extracellular matrix, integrin, neural tube closure, zebrafish
- MeSH Terms
-
- Adhesives
- Animals
- Extracellular Matrix/physiology
- Female
- Fibronectins/physiology*
- Humans
- Male
- Mesoderm/physiology*
- Morphogenesis*
- Neural Tube/growth & development*
- Spine/anatomy & histology
- Spine/growth & development*
- Zebrafish/physiology
- PubMed
- 32228864 Full text @ Elife
Citation
Guillon, E., Das, D., Jülich, D., Hassan, A.R., Geller, H., Holley, S. (2020) Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development. eLIFE. 9:.
Abstract
An extracellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate development. Here, we find that the bilaterally symmetric interfaces between the zebrafish neural tube and paraxial mesoderm function as optimally engineered adhesive lap joints with rounded edges, graded Fibronectin 'adhesive' and an arced adhesive spew filet. Fibronectin is a 'smart adhesive' that remodels to the lateral edges of the neural tube-paraxial mesoderm interfaces where shear stress is highest. Fibronectin remodeling is mechanically responsive to contralateral variation morphogenesis, and Fibronectin-mediated inter-tissue adhesion is required for bilaterally symmetric morphogenesis of the paraxial mesoderm. Strikingly, however, perturbation of the Fibronectin matrix rescues the neural tube convergence defect of cadherin 2 mutants. Therefore, Fibronectin-mediated inter-tissue adhesion dynamically coordinates bilaterally symmetric morphogenesis of the vertebrate trunk but predisposes the neural tube to convergence defects that lead to spina bifida.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping