PUBLICATION

Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation

Authors
Chan, S.H., Tang, Y., Miao, L., Darwich-Codore, H., Vejnar, C.E., Beaudoin, J.D., Musaev, D., Fernandez, J.P., Benitez, M.D.J., Bazzini, A.A., Moreno-Mateos, M.A., Giraldez, A.J.
ID
ZDB-PUB-190619-9
Date
2019
Source
Developmental Cell   49: 867-881.e8 (Journal)
Registered Authors
Fernandez, Juan Pablo, Giraldez, Antonio, Miao, Liyun, Vejnar, Charles
Keywords
cell reprogramming, embryonic development, genome activation, histone modifications, live imaging, maternal-to-zygotic transition, transcription, transcriptional activation, zebrafish, zygotic genome activation
MeSH Terms
  • Animals
  • E1A-Associated p300 Protein/genetics
  • E1A-Associated p300 Protein/metabolism
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/metabolism*
  • Embryonic Development*
  • Gene Expression Regulation, Developmental*
  • Genome*
  • Regulatory Sequences, Nucleic Acid
  • Transcription Factors/genetics
  • Transcription Factors/metabolism
  • Transcriptional Activation
  • Transcriptome
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Zygote/cytology
  • Zygote/metabolism*
PubMed
31211993 Full text @ Dev. Cell
Abstract
The awakening of the genome after fertilization is a cornerstone of animal development. However, the mechanisms that activate the silent genome after fertilization are poorly understood. Here, we show that transcriptional competency is regulated by Brd4- and P300-dependent histone acetylation in zebrafish. Live imaging of transcription revealed that genome activation, beginning at the miR-430 locus, is gradual and stochastic. We show that genome activation does not require slowdown of the cell cycle and is regulated through the translation of maternally inherited mRNAs. Among these, the enhancer regulators P300 and Brd4 can prematurely activate transcription and restore transcriptional competency when maternal mRNA translation is blocked, whereas inhibition of histone acetylation blocks genome activation. We conclude that P300 and Brd4 are sufficient to trigger genome-wide transcriptional competency by regulating histone acetylation on the first zygotic genes in zebrafish. This mechanism is critical for initiating zygotic development and developmental reprogramming.
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