PUBLICATION
Sleep Deprivation caused a Memory Defects and Emotional Changes in a Rotenone-based Zebrafish Model of Parkinson's Disease
- Authors
- Lv, D.J., Li, L.X., Chen, J., Wei, S.Z., Wang, F., Hu, H., Xie, A.M., Liu, C.F.
- ID
- ZDB-PUB-190614-13
- Date
- 2019
- Source
- Behavioural brain research 372: 112031 (Journal)
- Registered Authors
- Li, Lingxi, Liu, Chun-Feng, Lv, Dongjun, Wang, Fen
- Keywords
- Dopamine, Emotion, Memory, Parkinson’s Disease, Sleep Deprivation
- MeSH Terms
-
- 3,4-Dihydroxyphenylacetic Acid/metabolism
- Animals
- Cognition/physiology
- Disease Models, Animal
- Dopamine/metabolism
- Emotions/physiology*
- Male
- Memory/physiology*
- Motor Activity
- Parkinson Disease/physiopathology
- Rotenone/pharmacology
- Sleep Deprivation/metabolism
- Sleep Deprivation/physiopathology*
- Zebrafish/metabolism
- Zebrafish/physiology
- PubMed
- 31195038 Full text @ Behav. Brain Res.
Citation
Lv, D.J., Li, L.X., Chen, J., Wei, S.Z., Wang, F., Hu, H., Xie, A.M., Liu, C.F. (2019) Sleep Deprivation caused a Memory Defects and Emotional Changes in a Rotenone-based Zebrafish Model of Parkinson's Disease. Behavioural brain research. 372:112031.
Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the world. Apart from motor deficits, PD reduces patient's quality of life through sleep disturbances, cognitive impairment and emotional disorders. However, it's unclear whether bad life habits such as stay up late exacerbate the patient's cognition and emotional disorders. Thus we investigated the consequences of sleep deprivation (SD) on memory and emotions using a rotenone-based zebrafish model of PD. Behavioral assays, using locomotor activity assay, showed that rotenone treated zebrafish exhibited PD-like symptoms, whereas sleep deprivation didn't exacerbate the progression of them. The object discrimination task exhibited that the short-term cognitive deficits of rotenone group are more serious than the sham group after SD. Light-dark box test showed that rotenone treated fish are more dysphoric than the sham fish after SD. Dopamine and DOPAC significantly reduced in rotenone treated fish compared with the sham fish. However, this DOPAC reduction recovered after SD. The expression of D2 and D3 in rotenone treated zebrafish elevated compared with sham group and SD group. However, the rotenone treated zebrafish manifested a decrease level of D2 and D3 after SD. D1 did not show any significantly changes among the four groups. Our findings suggest that zebrafish treated with rotenone may have a more severe damage of memory and emotional function after SD, which may be related to the changes in the DA systems.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping