PUBLICATION
Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans
- Authors
- Progatzky, F., Jha, A., Wane, M., Thwaites, R.S., Makris, S., Shattock, R.J., Johansson, C., Openshaw, P.J., Bugeon, L., Hansel, T.T., Dallman, M.J.
- ID
- ZDB-PUB-190422-18
- Date
- 2019
- Source
- The Journal of allergy and clinical immunology 144(1): 342-345.e7 (Journal)
- Registered Authors
- Bugeon, Laurence, Dallman, Maggie, Progatzky, Fränze
- Keywords
- comparative cross-species analysis, mucosal innate immunity, nasal respiratory mucosa, resiquimod, vaccine adjuvants
- MeSH Terms
-
- Female
- Adult
- Middle Aged
- Toll-Like Receptors/agonists*
- Gills/drug effects
- Gills/immunology
- Zebrafish
- Cytokines/immunology*
- Respiratory Mucosa/drug effects*
- Respiratory Mucosa/immunology
- Animals
- Mice, Inbred C57BL
- Humans
- Immunity, Mucosal/drug effects
- Immunity, Innate/drug effects
- Imidazoles/pharmacology*
- Male
- PubMed
- 31002833 Full text @ J. Allergy Clin. Immunol.
Citation
Progatzky, F., Jha, A., Wane, M., Thwaites, R.S., Makris, S., Shattock, R.J., Johansson, C., Openshaw, P.J., Bugeon, L., Hansel, T.T., Dallman, M.J. (2019) Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans. The Journal of allergy and clinical immunology. 144(1):342-345.e7.
Abstract
We compared live zebrafish, mouse and human nasal challenge responses to the TLR7/8 agonist resiquimod (R848). We found remarkably similar induction of mediators in the three species, offering novel mucosal models of innate anti-viral immunity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping