PUBLICATION
Endothelin neurotransmitter signalling controls zebrafish social behaviour
- Authors
- Carreño Gutiérrez, H., Colanesi, S., Cooper, B., Reichmann, F., Young, A.M.J., Kelsh, R.N., Norton, W.H.J.
- ID
- ZDB-PUB-190301-5
- Date
- 2019
- Source
- Scientific Reports 9: 3040 (Journal)
- Registered Authors
- Kelsh, Robert, Norton, Will
- Keywords
- none
- MeSH Terms
-
- Aggression/physiology*
- Animals
- Animals, Genetically Modified
- Arginine Vasopressin/metabolism
- Behavior Observation Techniques
- Behavior, Animal/physiology*
- Brain/metabolism
- Dopamine/metabolism
- Endothelins/metabolism*
- Female
- Male
- Models, Animal
- Neurons/metabolism
- Receptors, Endothelin/genetics
- Receptors, Endothelin/metabolism*
- Serotonin/metabolism
- Zebrafish
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 30816294 Full text @ Sci. Rep.
Citation
Carreño Gutiérrez, H., Colanesi, S., Cooper, B., Reichmann, F., Young, A.M.J., Kelsh, R.N., Norton, W.H.J. (2019) Endothelin neurotransmitter signalling controls zebrafish social behaviour. Scientific Reports. 9:3040.
Abstract
The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa-/- mutants exhibit heightened aggression and decreased whole-body cortisol levels suggesting that they are dominant. These behavioural changes correlate with a reduction of parvocellular arginine vasopressin (AVP)-positive neurons in the preoptic area, an increase in the size of magnocellular AVP neurons and a higher concentration of 5-HT and dopamine in the brain. Manipulation of AVP or 5-HT signalling can rescue the shoaling phenotype of ednraa-/- providing an insight into how the brain controls social interactions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping