PUBLICATION
Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community
- Authors
- Strungaru, S.A., Plavan, G., Ciobica, A., Nicoara, M., Robea, M.A., Solcan, C., Petrovici, A.
- ID
- ZDB-PUB-190121-4
- Date
- 2019
- Source
- Ecotoxicology and environmental safety 171: 854-862 (Journal)
- Registered Authors
- Keywords
- Aggressive behavior, Deltamethrin, Harmful effects, Immunocytochemistry, Neurotoxicity, Zebrafish
- MeSH Terms
-
- Aggression/drug effects
- Animals
- Fresh Water
- Insecticides/toxicity*
- Models, Biological
- Nervous System/drug effects
- Nervous System/pathology
- Nitriles/toxicity*
- Pyrethrins/toxicity*
- Swimming
- Water Pollutants, Chemical/toxicity*
- Zebrafish/anatomy & histology
- Zebrafish/physiology
- PubMed
- 30660979 Full text @ Ecotoxicol. Environ. Saf.
Citation
Strungaru, S.A., Plavan, G., Ciobica, A., Nicoara, M., Robea, M.A., Solcan, C., Petrovici, A. (2019) Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community. Ecotoxicology and environmental safety. 171:854-862.
Abstract
In this study zebrafish specimens were exposed for 15 days to 0.25, 0.5, 1 and 2 μg L-1 non-lethal concentrations of deltamethrin (DM) knowing that is the active compound in insecticides used on agricultural crops. They were investigated important issues resulted during the chronic exposure with DM: effects on aggressive behavior and swimming performances knowing that is a high neurotoxic compound; toxicity on nervous system investigated on telencephalon, optic tectum and cerebellum; activity of PCNA, p53 and TUNEL as toxicity markers in immunocytochemistry of the histological samples; changes of elements concentrations in the fish body and their role in detoxification of DM. This scenario investigated the harmful effects of this compound for freshwater fish communities. The aggressive behavior significantly increased and remained constant for the concentration 0.5 μg L-1. They were not evidences in changing of anxiety level and swimming performances. The nervous system suffered significant damage for all studied concentrations and confirmed the changes in the behavior. Selenium concentration in the body decreased and may be involved in the detoxification processes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping