PUBLICATION
Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4
- Authors
- Hehr, C.L., Halabi, R., McFarlane, S.
- ID
- ZDB-PUB-180703-2
- Date
- 2018
- Source
- Cell adhesion & migration 12(5): 489-502 (Journal)
- Registered Authors
- Halabi, Rami, Hehr, Carrie, McFarlane, Sarah
- Keywords
- Tumour necrosis factor receptor-associated factor 4, adherens junction, apico-basal polarity, evagination, eye vesicle, zebrafish
- MeSH Terms
- none
- PubMed
- 29961393 Full text @ Cell Adh. Migr.
Citation
Hehr, C.L., Halabi, R., McFarlane, S. (2018) Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4. Cell adhesion & migration. 12(5):489-502.
Abstract
During development, neuroepithelial progenitors acquire apico-basal polarity and adhere to one another via apically located tight and adherens junction complexes. This polarized neuroepithelium must continue to integrate cells arising through cell divisions and intercalation, and allow for cell movements, at the same time as undergoing morphogenesis. Cell proliferation, migration and intercalation all occur in the morphing embryonic eye. To understand how eye development might depend on dynamic epithelial adhesion, we investigated the function of a known regulator of junctional plasticity, Tumour necrosis factor receptor-associated factor 4 (Traf4). traf4a mRNA is expressed in the developing eye vesicle over the period of optic cup morphogenesis, and Traf4a loss leads to disrupted evagination and elongation of the eye vesicles, and aberrant organization and apico-basal polarity of the eye epithelium. We propose a model whereby Traf4a regulates apical junction plasticity in nascent eye epithelium, allowing for its polarization and morphogenesis.
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