PUBLICATION
Fox proteins are modular competency factors for facial cartilage and tooth specification
- Authors
- Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G.
- ID
- ZDB-PUB-180520-1
- Date
- 2018
- Source
- Development (Cambridge, England) 145(12): (Journal)
- Registered Authors
- Balczerski, Bartosz, Crump, Gage DeKoeyer, Huysseune, Ann
- Keywords
- Bone, Cartilage, Craniofacial, Forkhead, Foxc1, Foxf1, Foxf2, Pharyngeal arches, Sox9, Teeth, Zebrafish
- MeSH Terms
-
- Animals
- Body Patterning*/genetics
- Bone and Bones/metabolism
- Branchial Region/metabolism
- Cartilage/embryology*
- Cartilage/metabolism*
- Cell Proliferation/genetics
- Cell Survival/genetics
- Chondrogenesis/genetics
- Face
- Forkhead Transcription Factors/genetics
- Forkhead Transcription Factors/metabolism*
- Gene Expression Regulation, Developmental
- Mutation/genetics
- Neural Crest/cytology
- Signal Transduction
- Skull/cytology
- Tooth/embryology*
- Tooth/metabolism*
- Zebrafish/embryology
- Zebrafish Proteins/metabolism
- PubMed
- 29777011 Full text @ Development
Citation
Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G. (2018) Fox proteins are modular competency factors for facial cartilage and tooth specification. Development (Cambridge, England). 145(12).
Abstract
Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify these cell types remains a mystery. We find that modular expression of Forkhead-domain transcription factors (Fox) in the zebrafish face arises through integration of Hh, Fgf, Bmp, Edn1, and Jagged-Notch pathways. Whereas loss of C-class Fox proteins results in reduced upper facial cartilages, loss of F-class Fox proteins results in distal jaw truncations and absent midline cartilages and teeth. We show that Fox proteins are required for Sox9a to promote chondrogenic gene expression. Fox proteins are sufficient in neural crest-derived cells for cartilage development, and neural crest-specific misexpression of Fox proteins expands the cartilage domain while inhibiting bone. These results support a modular role for Fox proteins in establishing the competency of progenitors to form cartilage and teeth in the face.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping