PUBLICATION
Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour
- Authors
- Gutiérrez, H.C., O'Leary, A., Freudenberg, F., Fedele, G., Wilkinson, R., Markham, E., van Eeden, F., Reif, A., Norton, W.H.J.
- ID
- ZDB-PUB-170928-4
- Date
- 2017
- Source
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 30: 30-43 (Journal)
- Registered Authors
- van Eeden, Freek, Wilkinson, Robert
- Keywords
- Aggression, Anxiety, Monoamine oxidase, Mouse, Nitric oxide, Zebrafish
- MeSH Terms
-
- Aggression/drug effects
- Aggression/physiology*
- Aggression/psychology
- Animals
- Animals, Genetically Modified
- Anxiety/metabolism*
- Anxiety/psychology
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Monoamine Oxidase/metabolism*
- Monoamine Oxidase Inhibitors/pharmacology
- Nitric Oxide/metabolism*
- Nitric Oxide Synthase Type I/deficiency*
- Serotonin/metabolism
- Serotonin 5-HT1 Receptor Agonists/pharmacology
- Zebrafish
- PubMed
- 28951000 Full text @ Eur Neuropsychopharmacol
Citation
Gutiérrez, H.C., O'Leary, A., Freudenberg, F., Fedele, G., Wilkinson, R., Markham, E., van Eeden, F., Reif, A., Norton, W.H.J. (2017) Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 30:30-43.
Abstract
Nitric oxide (NO) is a gaseous neurotransmitter that has important behavioural functions in the vertebrate brain. In this study we compare the impact of decreased nitric NO signalling upon behaviour and neurobiology using both zebrafish and mouse. nitric oxide synthase mutant (nos1-/-) zebrafish show significantly reduced aggression and an increase in anxiety-like behaviour without altered production of the stress hormone cortisol. Nos1-/- mice also exhibit decreased aggression and are hyperactive in an open field test. Upon reduction of NO signalling, monoamine neurotransmitter metabolism is reduced as a consequence of decreased Monoamine oxidase activity. Treatment of nos1-/- zebrafish with the 5-HT receptor 1A agonist 8-OH-DPAT rescues aggression and some aspects of anxiety-like behaviour. Taken together, the interplay between NO and 5-HT appears to be critical to control behaviour. Our cross-species approach challenges the previous notion that reduced neuronal NOS leads to increased aggression. Rather, Nos1 knock-out can also lead to decreased aggression in some situations, a finding that may have implications for future translational research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping