PUBLICATION
MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin
- Authors
- Gu, W., Zhan, H., Zhou, X.Y., Yao, L., Yan, M., Chen, A., Liu, J., Ren, X., Zhang, X., Liu, J.X., Liu, G.
- ID
- ZDB-PUB-170124-3
- Date
- 2017
- Source
- FEBS letters 591(3): 513-526 (Journal)
- Registered Authors
- Liu, Jing-xia
- Keywords
- VE-cadherin, endothelial inflammation, miR-22, vascular development
- MeSH Terms
-
- 3' Untranslated Regions/genetics
- Animals
- Antigens, CD/genetics
- Antigens, CD/metabolism*
- Base Sequence
- Binding Sites
- Cadherins/genetics
- Cadherins/metabolism*
- Down-Regulation/genetics
- Embryo, Nonmammalian/metabolism
- Endothelium/pathology
- Human Umbilical Vein Endothelial Cells/metabolism
- Inflammation/genetics*
- Inflammation/pathology
- Mice
- MicroRNAs/genetics
- MicroRNAs/metabolism*
- Neovascularization, Physiologic/genetics*
- Protein Binding
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Zebrafish/embryology
- Zebrafish/genetics*
- PubMed
- 28112401 Full text @ FEBS Lett.
Citation
Gu, W., Zhan, H., Zhou, X.Y., Yao, L., Yan, M., Chen, A., Liu, J., Ren, X., Zhang, X., Liu, J.X., Liu, G. (2017) MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin. FEBS letters. 591(3):513-526.
Abstract
The vascular endothelial (VE)-cadherin functions as an endothelial barrier protein controlling endothelial permeability and leukocyte transmigration. Developmental studies indicate that VE-cadherin also plays a vital role in angiogenesis. MicroRNA-22 plays important roles in cardiovascular diseases including cardiac hypertrophy and heart failure. We identified that miR-22 interacts with VE-cadherin mRNA. Overexpression of miR-22 in endothelial cells increases the synthesis of pro-inflammatory cytokines. Injection of miR-22 results in increased myeloperoxidase activity in the mouse lungs. Moreover, miR-22 injection into the fluorescent-labeled transgenic zebrafish Tg(fli1:EGFP) embryos caused defective vascular development in the dorsal and intersegmental vessels, and vascular markers were significantly suppressed in these embryos. Our studies demonstrate that the conserved targeting of VE-cadherin by miR-22 regulates endothelial inflammation, tissue injury, and angiogenesis. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping