PUBLICATION
Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history
- Authors
- Nomiyama, H., Osada, N., and Yoshie, O.
- ID
- ZDB-PUB-140618-6
- Date
- 2013
- Source
- Genes to cells : devoted to molecular & cellular mechanisms 18(1): 1-16 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Chemokines/classification*
- Chemokines/genetics
- Chemokines/metabolism
- Evolution, Molecular*
- Genome, Human
- Humans
- Multigene Family
- Phylogeny
- Receptors, Chemokine/genetics
- Receptors, Chemokine/metabolism
- Synteny*
- PubMed
- 23145839 Full text @ Genes Cells
Citation
Nomiyama, H., Osada, N., and Yoshie, O. (2013) Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history. Genes to cells : devoted to molecular & cellular mechanisms. 18(1):1-16.
Abstract
The genes involved in host defences are known to undergo rapid evolution. Therefore, it is often difficult to assign orthologs in multigene families among various vertebrate species. Chemokines are a large family of small cytokines that orchestrate cell migration in health and disease. Herein, we have surveyed the genomes of 18 representative vertebrate species for chemokine genes and identified a total of 553 genes. We have determined their orthologous relationships and classified them in accordance with the current systematic chemokine nomenclature system. Our study reveals an interesting evolutionary history that gave origin and diversification to the vertebrate chemokine superfamily.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping