PUBLICATION
Wnt-regulated dynamics of positional information in zebrafish somitogenesis
- Authors
- Bajard, L., Morelli, L.G., Ares, S., Pécréaux, J., Jülicher, F., Oates, A.C.
- ID
- ZDB-PUB-140513-413
- Date
- 2014
- Source
- Development (Cambridge, England) 141: 1381-91 (Journal)
- Registered Authors
- Oates, Andrew
- Keywords
- Embryonic elongation, Fgf signaling, Segmentation clock, Signal gradient, Time-lapse microscopy, Wnt signaling
- MeSH Terms
-
- Somites/embryology*
- Somites/metabolism*
- Basic Helix-Loop-Helix Transcription Factors/genetics
- Basic Helix-Loop-Helix Transcription Factors/physiology
- Models, Biological
- Intercellular Signaling Peptides and Proteins/genetics
- Intercellular Signaling Peptides and Proteins/physiology
- Animals
- Heat-Shock Response/genetics
- Heat-Shock Response/physiology
- T-Box Domain Proteins/genetics
- T-Box Domain Proteins/physiology
- Zebrafish Proteins/antagonists & inhibitors
- Zebrafish Proteins/genetics
- Zebrafish Proteins/physiology*
- Gene Expression Regulation, Developmental
- Fibroblast Growth Factors/genetics
- Fibroblast Growth Factors/physiology
- Animals, Genetically Modified
- Body Patterning/genetics
- Body Patterning/physiology
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism*
- Wnt Signaling Pathway/genetics
- Wnt Signaling Pathway/physiology*
- Wnt Proteins/antagonists & inhibitors
- Wnt Proteins/genetics
- Wnt Proteins/physiology
- PubMed
- 24595291 Full text @ Development
Citation
Bajard, L., Morelli, L.G., Ares, S., Pécréaux, J., Jülicher, F., Oates, A.C. (2014) Wnt-regulated dynamics of positional information in zebrafish somitogenesis. Development (Cambridge, England). 141:1381-91.
Abstract
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping