PUBLICATION
ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/beta-catenin
- Authors
- Lush, M.E., Piotrowski, T.
- ID
- ZDB-PUB-140513-325
- Date
- 2014
- Source
- eLIFE 3: e01832 (Journal)
- Registered Authors
- Lush, Mark E., Piotrowski, Tatjana
- Keywords
- glia, neuromast, stem cells
- MeSH Terms
-
- Zebrafish/genetics
- Zebrafish/metabolism
- beta Catenin/genetics
- beta Catenin/metabolism*
- Mutation
- Time Factors
- Receptors, Notch/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- Genotype
- Gene Expression Regulation, Developmental
- Lateral Line System/cytology
- Lateral Line System/drug effects
- Lateral Line System/metabolism*
- Phenotype
- Protein Kinase Inhibitors/pharmacology
- Cell Differentiation
- Cell Communication*/drug effects
- Neural Stem Cells/drug effects
- Neural Stem Cells/metabolism*
- Wnt Signaling Pathway*/drug effects
- Animals, Genetically Modified
- Cell Proliferation
- Neuregulins/metabolism
- Stem Cell Niche
- Animals
- Fibroblast Growth Factors/metabolism
- Schwann Cells/drug effects
- Schwann Cells/metabolism*
- PubMed
- 24642408 Full text @ Elife
Citation
Lush, M.E., Piotrowski, T. (2014) ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/beta-catenin. eLIFE. 3:e01832.
Abstract
Proper orchestration of quiescence and activation of progenitor cells is crucial during embryonic development and adult homeostasis. We took advantage of the zebrafish sensory lateral line to define niche-progenitor interactions to understand how integration of diverse signaling pathways spatially and temporally regulates the coordination of these processes. Our previous studies demonstrated that Schwann cells play a crucial role in negatively regulating lateral line progenitor proliferation. Here we demonstrate that ErbB/Neuregulin signaling is not only required for Schwann cell migration but that it plays a continued role in postmigratory Schwann cells. ErbB expressing Schwann cells inhibit lateral line progenitor proliferation and differentiation through non-cell-autonomous inhibition of Wnt/β-catenin signaling. Subsequent activation of Fgf signaling controls sensory organ differentiation, but not progenitor proliferation. In addition to the lateral line, these findings have important implications for understanding how niche-progenitor cells segregate interactions during development, and how they may go wrong in disease states.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping