PUBLICATION

Neuronal Expression of Fibroblast Growth Factor Receptors in Zebrafish

Authors
Rohs, P., Ebert, A.M., Zuba, A., and McFarlane, S.
ID
ZDB-PUB-130722-17
Date
2013
Source
Gene expression patterns : GEP   13(8): 354-61 (Journal)
Registered Authors
Keywords
mRNA expression, development, embryonic, Danio rerio
MeSH Terms
  • Animals
  • Brain/cytology
  • Brain/metabolism*
  • Gene Expression*
  • Gene Expression Regulation, Developmental
  • Neurons/metabolism*
  • Organ Specificity
  • Receptor, Fibroblast Growth Factor, Type 1/genetics
  • Receptor, Fibroblast Growth Factor, Type 1/metabolism
  • Receptor, Fibroblast Growth Factor, Type 2/genetics
  • Receptor, Fibroblast Growth Factor, Type 2/metabolism
  • Receptor, Fibroblast Growth Factor, Type 3/genetics
  • Receptor, Fibroblast Growth Factor, Type 3/metabolism
  • Receptor, Fibroblast Growth Factor, Type 4/genetics
  • Receptor, Fibroblast Growth Factor, Type 4/metabolism
  • Zebrafish/embryology
  • Zebrafish/metabolism*
PubMed
23850987 Full text @ Gene Expr. Patterns
Abstract

Fibroblast growth factor (FGF) signaling is important for a host of developmental processes such as proliferation, differentiation, tissue patterning, and morphogenesis. In vertebrates, FGFs signal through a family of four fibroblast growth factor receptors (FGFR 1-4), one of which is duplicated in zebrafish (FGFR1). Here we report the mRNA expression of the five known zebrafish fibroblast growth factor receptors at five developmental time points (24, 36, 48, 60, and 72 h postfertilization), focusing on expression within the central nervous system. We show that the receptors have distinct and dynamic expression in the developing zebrafish brain, eye, inner ear, lateral line, and pharynx. In many cases, these expression patterns are similar to that of homologous FGFRs in mouse, chicken, amphibians, and other teleosts.

Genes / Markers
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping