Cloning and developmental expression of zebrafish pdzrn3
- Authors
- Dente, L., Gestri, G., Tsang, M., Kudoh, T., Wilson, S.W., Dawid, I.B., and Andreazzoli, M.
- ID
- ZDB-PUB-120125-14
- Date
- 2011
- Source
- The International journal of developmental biology 55(10-12): 989-993 (Journal)
- Registered Authors
- Andreazzoli, Massimiliano, Dawid, Igor B., Gestri, Gaia, Kudoh, Tetsuhiro, Tsang, Michael, Wilson, Steve
- Keywords
- PDZRN protein, PDZ domain, RING finger, zebrafish development, ventral retina
- MeSH Terms
-
- Sequence Homology, Amino Acid
- Gene Expression Regulation, Developmental*
- Cloning, Molecular
- Molecular Sequence Data
- Retina/embryology
- Retina/metabolism
- Time Factors
- Motor Neurons/metabolism
- Thalamus/embryology
- Protein Structure, Tertiary
- Animals
- In Situ Hybridization
- Gene Expression Profiling
- Amino Acid Sequence
- Zebrafish Proteins/biosynthesis
- Zebrafish Proteins/genetics*
- Mutation
- Carrier Proteins/biosynthesis
- Carrier Proteins/genetics*
- PubMed
- 22252497 Full text @ Int. J. Dev. Biol.
Pdzrn3, a member of the PDZRN/SEMCAP/LNX protein family containing a RING finger and two PDZ domains, has been implicated in myoblast and osteoblast differentiation. However, its spatio-temporal expression pattern during embryonic development has not been defined. Here, we describe the cloning and expression pattern of pdzrn3 during zebrafish development. We found that in addition to being expressed in several mesodermal structures, this gene displays specific expression in the central nervous system including rhombomere 1, ventral retina, thalamus and motor neurons, indicating a novel function during neural development. In particular, the absence of expression of pdzrn3 in the ventral retina of noi mutant fish suggests a possible role for this gene in regulating fasciculation and/or navigation of retinal ganglion cell axons.