PUBLICATION
The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio
- Authors
- Shen, Y.C., Thompson, D.L., Kuah, M.K., Wong, K.L., Wu, K.L., Linn, S.A., Jewett, E.M., Shu-Chien, A.C., and Barald, K.F.
- ID
- ZDB-PUB-120111-4
- Date
- 2012
- Source
- Developmental Biology 363(1): 84-94 (Journal)
- Registered Authors
- Barald, Kate, Shen, YuChi
- Keywords
- zebrafish, macrophage migration inhibitory factory, inner ear, sensory HC, statoacoustic ganglion, immune cytokines, neurotrophin
- MeSH Terms
-
- Animals
- Cell Differentiation/genetics
- Ear, Inner/embryology
- Ear, Inner/metabolism*
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/embryology
- Embryo, Nonmammalian/metabolism
- Ganglia, Sensory/embryology
- Ganglia, Sensory/metabolism
- Gene Expression Profiling
- Gene Expression Regulation, Developmental/drug effects
- Gene Knockdown Techniques
- Hair Cells, Auditory/metabolism
- Histone Deacetylase Inhibitors/pharmacology
- Hydroxamic Acids/pharmacology
- Macrophage Migration-Inhibitory Factors/genetics*
- Macrophage Migration-Inhibitory Factors/metabolism
- Nerve Growth Factors/genetics*
- Pyrimidines/pharmacology
- Receptors, Immunologic/genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Semicircular Canals/embryology
- Semicircular Canals/metabolism
- Sensory Receptor Cells/cytology
- Sensory Receptor Cells/metabolism
- Time Factors
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish Proteins/genetics*
- PubMed
- 22210003 Full text @ Dev. Biol.
Citation
Shen, Y.C., Thompson, D.L., Kuah, M.K., Wong, K.L., Wu, K.L., Linn, S.A., Jewett, E.M., Shu-Chien, A.C., and Barald, K.F. (2012) The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. Developmental Biology. 363(1):84-94.
Abstract
Macrophage migration inhibitory factor (MIF) plays versatile roles in the immune system. MIF is also widely expressed during embryonic development, particularly in the nervous system, although its roles in neural development are only beginning to be understood. Evidence from frogs, mice and zebrafish suggests that MIF has a major role as a neurotrophin in the early development of sensory systems, including the auditory system. Here we show that the zebrafish mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell survival in the ear, for HC differentiation, semicircular canal formation, statoacoustic ganglion (SAG) development, and lateral line HC differentiation. This is consistent with our findings that MIF is expressed in the developing mammalian and avian auditory systems and promotes mouse and chick SAG neurite outgrowth and neuronal survival, demonstrating key instructional roles for MIF in vertebrate otic development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping