PUBLICATION
Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain
- Authors
- Koyama, M., Kinkhabwala, A., Satou, C., Higashijima, S.I., and Fetcho, J.
- ID
- ZDB-PUB-110110-13
- Date
- 2011
- Source
- Proceedings of the National Academy of Sciences of the United States of America 108(3): 1170-1175 (Journal)
- Registered Authors
- Fetcho, Joseph R., Higashijima, Shin-ichi
- Keywords
- development, locomotion, neuronal circuit, Mauthner neuron
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Body Patterning/physiology*
- Brain Mapping/methods*
- Electrophysiology
- Escape Reaction/physiology*
- Image Processing, Computer-Assisted
- Immunohistochemistry
- Interneurons/metabolism
- Larva/anatomy & histology
- Larva/physiology
- Nerve Net*
- Patch-Clamp Techniques
- Psychomotor Performance/physiology
- Rhombencephalon/anatomy & histology
- Rhombencephalon/physiology*
- Zebrafish/anatomy & histology
- Zebrafish/physiology*
- PubMed
- 21199937 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Koyama, M., Kinkhabwala, A., Satou, C., Higashijima, S.I., and Fetcho, J. (2011) Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain. Proceedings of the National Academy of Sciences of the United States of America. 108(3):1170-1175.
Abstract
The hindbrain of larval zebrafish contains a relatively simple ground plan in which the neurons throughout it are arranged into stripes that represent broad neuronal classes that differ in transmitter identity, morphology, and transcription factor expression. Within the stripes, neurons are stacked continuously according to age as well as structural and functional properties, such as axonal extent, input resistance, and the speed at which they are recruited during movements. Here we address the question of how particular networks among the many different sensory-motor networks in hindbrain arise from such an orderly plan. We use a combination of transgenic lines and pairwise patch recording to identify excitatory and inhibitory interneurons in the hindbrain network for escape behaviors initiated by the Mauthner cell. We map this network onto the ground plan to show that an individual hindbrain network is built by drawing components in predictable ways from the underlying broad patterning of cell types stacked within stripes according to their age and structural and functional properties. Many different specialized hindbrain networks may arise similarly from a simple early patterning.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping