PUBLICATION
Focusing on optic tectum circuitry through the lens of genetics
- Authors
- Nevin, L.M., Robles, E., Baier, H., and Scott, E.K.
- ID
- ZDB-PUB-101011-44
- Date
- 2010
- Source
- BMC Biology 8: 126 (Review)
- Registered Authors
- Baier, Herwig, Nevin, Linda, Robles, Estuardo, Scott, Ethan
- Keywords
- none
- MeSH Terms
-
- Animals
- Models, Neurological*
- Nerve Net/anatomy & histology*
- Nerve Net/physiology
- Neurons/physiology*
- Superior Colliculi/anatomy & histology*
- Superior Colliculi/physiology
- Visual Pathways/metabolism
- Visual Pathways/physiology*
- Visual Perception/physiology*
- Zebrafish
- PubMed
- 20920150 Full text @ BMC Biol.
Citation
Nevin, L.M., Robles, E., Baier, H., and Scott, E.K. (2010) Focusing on optic tectum circuitry through the lens of genetics. BMC Biology. 8:126.
Abstract
The visual pathway is tasked with processing incoming signals from the retina and converting this information into adaptive behavior. Recent studies of the larval zebrafish tectum have begun to clarify how the 'micro-circuitry' of this highly organized midbrain structure filters visual input, which arrives in the superficial layers and directs motor output through efferent projections from its deep layers. The new emphasis has been on the specific function of neuronal cell types, which can now be reproducibly labeled, imaged and manipulated using genetic and optical techniques. Here, we discuss recent advances and emerging experimental approaches for studying tectal circuits as models for visual processing and sensorimotor transformation by the vertebrate brain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping