PUBLICATION
The expression patterns of minor fibrillar collagens during development in zebrafish
- Authors
- Fang, M., Adams, J.S., McMahan, B.L., Brown, R.J., and Oxford, J.T.
- ID
- ZDB-PUB-100726-15
- Date
- 2010
- Source
- Gene expression patterns : GEP 10(7-8): 315-322 (Journal)
- Registered Authors
- Keywords
- minor fibrillar collagens, zebrafish, development, in situ hybridization, Danio rerio
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Branchial Region/metabolism
- Disease Models, Animal
- Embryo, Nonmammalian/metabolism
- Extracellular Matrix/genetics
- Extracellular Matrix/metabolism
- Eye/embryology
- Eye/metabolism
- Fibrillar Collagens/chemistry
- Fibrillar Collagens/genetics*
- Fibrillar Collagens/metabolism*
- Gene Expression Profiling*
- Gene Expression Regulation, Developmental*
- In Situ Hybridization
- Mesoderm/cytology
- Neural Crest/metabolism
- Notochord/metabolism
- Polymerase Chain Reaction
- Sequence Alignment
- Somites/metabolism
- Spine/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics*
- Zebrafish/metabolism
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- PubMed
- 20647059 Full text @ Gene Expr. Patterns
Citation
Fang, M., Adams, J.S., McMahan, B.L., Brown, R.J., and Oxford, J.T. (2010) The expression patterns of minor fibrillar collagens during development in zebrafish. Gene expression patterns : GEP. 10(7-8):315-322.
Abstract
Minor fibrillar collagens are recognized as the organizers and nucleators during collagen fibrillogenesis but likely serve additional functions. The minor fibrillar collagens include collagens type V and type XI. Mutations of collagen type V and XI can cause Ehlers Danlos, Stickler's, and Marshall's syndromes in human. We have characterized the spatiotemporal expression patterns of Col11a1, Col11a2, Col5a1 as well as Col5a3 in zebrafish embryos by in situ hybridization. Col5a1 is expressed in developing somites, neural crest, the head mesenchyme, developing cranial cartilage, pharyngeal arches and vertebrae. Col5a3 is detected in the notochord, mesenchyme cells in the eyes and lens. Both Col11a1 and Col11a2 have similar expression patterns, including notochord, otic vesicle, and developing cranial cartilages. Zebrafish may therefore serve as a valuable vertebrate model system for the study of diseases associated with collagens type V and XI mutations.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping