PUBLICATION
Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling
- Authors
- Tee, J.M., van Rooijen, C., Boonen, R., and Zivkovic, D.
- ID
- ZDB-PUB-090616-54
- Date
- 2009
- Source
- PLoS One 4(6): e5880 (Journal)
- Registered Authors
- van Rooijen, Carina
- Keywords
- Embryos, Muscle fibers, Muscle differentiation, Somites, Fast-twitch muscle fibers, Slow-twitch muscle fibers, Wnt signaling cascade, Zebrafish
- MeSH Terms
-
- Animals
- Cell Proliferation
- Cyclin-Dependent Kinase Inhibitor p21/metabolism
- Epistasis, Genetic
- Gene Expression Regulation*
- Gene Expression Regulation, Developmental*
- Hypertrophy
- Muscle Fibers, Fast-Twitch/pathology*
- Muscle Fibers, Slow-Twitch/pathology*
- Muscles/embryology*
- Myostatin/metabolism*
- Signal Transduction
- Wnt Proteins/metabolism*
- Zebrafish/embryology*
- beta Catenin/metabolism*
- PubMed
- 19517013 Full text @ PLoS One
Citation
Tee, J.M., van Rooijen, C., Boonen, R., and Zivkovic, D. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS One. 4(6):e5880.
Abstract
Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-catenin signaling on fast muscle hypertrophy were rescued by misexpression of Myostatin or p21(CIP/WAF), establishing an in vivo regulation of myofibrillogenesis by Wnt/beta-catenin signaling and Myostatin. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping