PUBLICATION

Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton

Authors
Lin, F., Chen, S., Sepich, D.S., Panizzi, J.R., Clendenon, S.G., Marrs, J.A., Hamm, H.E., and Solnica-Krezel, L.
ID
ZDB-PUB-090330-5
Date
2009
Source
The Journal of cell biology   184(6): 909-921 (Journal)
Registered Authors
Clendenon, Sherry, Lin, Fang, Marrs, James A., Panizzi, Jennifer R., Sepich, Diane, Solnica-Krezel, Lilianna
Keywords
none
MeSH Terms
  • Actins/metabolism*
  • Animals
  • Cadherins/genetics
  • Cadherins/metabolism*
  • Cell Adhesion
  • Cell Movement
  • Cytoskeleton/enzymology
  • Cytoskeleton/metabolism*
  • GTP-Binding Protein alpha Subunits, G12-G13/genetics
  • GTP-Binding Protein alpha Subunits, G12-G13/metabolism*
  • Gastrula/enzymology
  • Gastrula/metabolism*
  • Gastrulation*
  • Gene Expression Regulation, Developmental
  • Guanine Nucleotide Exchange Factors/metabolism
  • Mutation
  • Protein Structure, Tertiary
  • Recombinant Fusion Proteins/metabolism
  • Signal Transduction*
  • Time Factors
  • Zebrafish
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • rho GTP-Binding Proteins/metabolism
PubMed
19307601 Full text @ J. Cell Biol.
Abstract
Epiboly spreads and thins the blastoderm over the yolk cell during zebrafish gastrulation, and involves coordinated movements of several cell layers. Although recent studies have begun to elucidate the processes that underlie these epibolic movements, the cellular and molecular mechanisms involved remain to be fully defined. Here, we show that gastrulae with altered Galpha(12/13) signaling display delayed epibolic movement of the deep cells, abnormal movement of dorsal forerunner cells, and dissociation of cells from the blastoderm, phenocopying e-cadherin mutants. Biochemical and genetic studies indicate that Galpha(12/13) regulate epiboly, in part by associating with the cytoplasmic terminus of E-cadherin, and thereby inhibiting E-cadherin activity and cell adhesion. Furthermore, we demonstrate that Galpha(12/13) modulate epibolic movements of the enveloping layer by regulating actin cytoskeleton organization through a RhoGEF/Rho-dependent pathway. These results provide the first in vivo evidence that Galpha(12/13) regulate epiboly through two distinct mechanisms: limiting E-cadherin activity and modulating the organization of the actin cytoskeleton.
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