PUBLICATION
Cadherin-7 function in zebrafish development
- Authors
- Liu, Q., Marrs, J.A., Londraville, R.L., and Wilson, A.L.
- ID
- ZDB-PUB-080801-16
- Date
- 2008
- Source
- Cell and tissue research 334(1): 37-45 (Journal)
- Registered Authors
- Liu, Qin, Marrs, James A.
- Keywords
- Cell adhesion molecules, Notochord, Central nervous system, Antisense morpholino oligonucleotides, Zebrafish, Danio rerio (Teleostei)
- MeSH Terms
-
- Animals
- Biomarkers/metabolism
- Cadherins/genetics
- Cadherins/physiology*
- Central Nervous System/drug effects
- Central Nervous System/embryology*
- Embryo, Nonmammalian/drug effects
- Embryo, Nonmammalian/physiology
- Gene Expression Regulation, Developmental
- Notochord/cytology
- Notochord/drug effects
- Notochord/physiology*
- Oligonucleotides, Antisense/genetics
- Zebrafish/embryology*
- Zebrafish/physiology
- Zebrafish Proteins/genetics
- Zebrafish Proteins/physiology*
- PubMed
- 18665394 Full text @ Cell Tissue Res.
Citation
Liu, Q., Marrs, J.A., Londraville, R.L., and Wilson, A.L. (2008) Cadherin-7 function in zebrafish development. Cell and tissue research. 334(1):37-45.
Abstract
Cadherin cell adhesion molecules play crucial roles in vertebrate development. Most studies have focused on examining the functions of classical type I cadherins (e.g., cadherin-2) in the development of vertebrates. Little information is available concerning the function of classical type II cadherins (e.g., cadherin-7) in vertebrate development. We have previously shown that cadherin-7 mRNA exhibits a dynamic expression pattern in the central nervous system and notochord in embryonic zebrafish. To gain insight into the role of cadherin-7 in the formation of these structures, we analyzed their formation in zebrafish embryos injected with cadherin-7-specific antisense morpholino oligonucleotides (MO). Notochord development was severely disrupted in MO-injected embryos, whereas gross defects in the development of the central nervous system were not detected in MO-injected embryos. Our results thus demonstrate that cadherin-7 plays an important role in the normal development of the zebrafish notochord.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping