PUBLICATION
Cranial neural crest and development of the head skeleton
- Authors
- Knight, R.D., and Schilling, T.F.
- ID
- ZDB-PUB-061108-6
- Date
- 2006
- Source
- Advances in experimental medicine and biology 589: 120-133 (Chapter)
- Registered Authors
- Knight, Robert, Schilling, Tom
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning
- Bone Development*
- Branchial Region/embryology
- Cartilage/metabolism
- Cell Movement
- Ectoderm/metabolism
- Endoderm/metabolism
- Gene Expression Regulation, Developmental*
- Humans
- Models, Anatomic
- Neural Crest/embryology*
- Zebrafish
- PubMed
- 17076278 Full text @ Adv. Exp. Med. Biol.
Citation
Knight, R.D., and Schilling, T.F. (2006) Cranial neural crest and development of the head skeleton. Advances in experimental medicine and biology. 589:120-133.
Abstract
The skeletal derivatives of the cranial neural crest (CNC) are patterned through a combination of intrinsic differences between crest cells and extrinsic signals from adjacent tissues, including endoderm and ectoderm. In this chapter, we focus on how CNC cells positionally interpret these cues to generate such highly specialized structures as the jaw and ear ossicles. We highlight recent genetic studies of craniofacial development in zebrafish that have revealed new tissue interactions and show that the process of CNC development is highly conserved across the vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping