PUBLICATION
Novel antizyme gene in Danio rerio expressed in brain and retina
- Authors
- Ivanov, I.P., Pittman, A.J., Chien, C.B., Gesteland, R.F., and Atkins, J.F.
- ID
- ZDB-PUB-061020-57
- Date
- 2007
- Source
- Gene 387(1-2): 87-92 (Journal)
- Registered Authors
- Chien, Chi-Bin, Pittman, Andrew
- Keywords
- Ornithine decarboxylase antizyme, Zebrafish, Retinal ganglion cell, Minnow
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Brain/metabolism*
- Enzyme Inhibitors/metabolism*
- Gene Expression Regulation, Developmental
- Molecular Sequence Data
- Ornithine Decarboxylase Inhibitors*
- Phylogeny
- Protein Biosynthesis
- Proteins/genetics
- Proteins/metabolism*
- Retina/metabolism*
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/metabolism*
- PubMed
- 17049757 Full text @ Gene
Citation
Ivanov, I.P., Pittman, A.J., Chien, C.B., Gesteland, R.F., and Atkins, J.F. (2007) Novel antizyme gene in Danio rerio expressed in brain and retina. Gene. 387(1-2):87-92.
Abstract
The synthesis of the protein antizyme requires a +1 ribosomal frameshift event. The frameshifting serves as a regulatory sensor. Antizyme homologs have been identified in diverse organisms ranging from yeast to human and characterized in a disparate subset. Most vertebrates have multiple antizyme paralogs. Here we present identification in the zebrafish Danio rerio of a heretofore unknown member of the antizyme gene family. This novel antizyme does not correspond to any of the known orthologous groups in vertebrates and unlike most other antizymes is preferentially expressed in the retinal ganglion cell layer of the eye. In addition to the retina, it is also expressed in the brain and somites.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping