PUBLICATION
Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy
- Authors
- Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H.,Poirier, F., and Griffioen, A.W.
- ID
- ZDB-PUB-061020-46
- Date
- 2006
- Source
- Proceedings of the National Academy of Sciences of the United States of America 103(43): 15975-15980 (Journal)
- Registered Authors
- Bakkers, Jeroen, Postel, Ruben
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Movement
- Cell Proliferation
- Cells, Cultured
- Disease Progression
- Endothelial Cells/metabolism
- Endothelial Cells/pathology
- Galectin 1/deficiency
- Galectin 1/genetics
- Galectin 1/metabolism*
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- Mice, Knockout
- Neoplasm Transplantation
- Neoplasms/blood supply*
- Neoplasms/genetics
- Neoplasms/metabolism*
- Neoplasms/therapy
- Protein Binding
- Proteins/metabolism
- Zebrafish
- PubMed
- 17043243 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H.,Poirier, F., and Griffioen, A.W. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proceedings of the National Academy of Sciences of the United States of America. 103(43):15975-15980.
Abstract
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping